SAMSN1 Antibody, HRP conjugated

Datasheet

Code	CSB-PA885722LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SAMSN1 Polyclonal antibody

Uniprot No.

Q9NSI8

Target Names

SAMSN1

Alternative Names

HACS1 antibody; Hematopoietic adapter containing SH3 and sterile α, motif (SAM) domains 1 antibody; Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1 antibody; Hematopoietic adaptor containing SH3 and SAM domains 1 antibody; Nash1 antibody; Nuclear localization signals SAM and SH3 domain containing 1 antibody; SAM and SH3 domain containing 2 antibody; SAM domain antibody; SAM domain containing protein SAMSN 1 antibody; SAM domain SH3 domain and nuclear localisation signals 1 antibody; SAM domain SH3 domain and nuclear localization signals 1 antibody; SAM domain, SH3 domain and nuclear localization signals protein 1 antibody; SAM domain-containing protein SAMSN-1 antibody; SAMN1_HUMAN antibody; SAMSN 1 antibody; Samsn1 antibody; SASH2 antibody; SH3 domain and nuclear localisation signals 1 antibody; SH3 domain and nuclear localization signals protein 1 antibody; SH3 SAM adaptor protein antibody; SH3-SAM adaptor protein antibody; SH3D6B antibody; SLy2 antibody; Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human SAM domain-containing protein SAMSN-1 protein (1-373AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.

Gene References into Functions

Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. PMID: 25805236
This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development. PMID: 25117979
High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of glioblastoma multiforme PMID: 24278465
the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading. PMID: 21296879
In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1. PMID: 20478393
HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. PMID: 15381729
downregulation of SAMSN1 gene in human lung cancer. PMID: 18523997

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Subcellular Location

Nucleus. Cytoplasm. Cell projection, ruffle.

Tissue Specificity

Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.

Database Links

HGNC: 10528

OMIM: 607978

KEGG: hsa:64092

STRING: 9606.ENSP00000383411

UniGene: Hs.473341

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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